It's got to be this scene for me:
"Brian: Can I borrow a tea-bag?
Tim: [sarcastically] Only if you bring it back. [pauses] You can HAVE a tea-bag,
Brian, you can't borrow one. [turns around, sees Brian dressed as a painting] You've got paint on you.
Brian: It's a literal tribute to the self reflexivity of Rembrandt.
Tim: Did he like it?
Brian: He's dead.
Tim: Bloody hell, that really backfired.
Brian: What are you playing?
Tim: Tomb Raider 3.
Brian: She's drowning.
Brian: Is that the point of the game?
Tim: Depends what mood you're in really.
Brian: What sort of mood are you in then?
Tim: Well, I got a letter from my ex-girlfriend this morning, 3 months too late, explaining why she dumped me. It was full of 'you'll always be special' and 'I'll always love you' platitudes designed to make me feel better whilst simultaneously appeasing her deep seated sense of guilt for dumping me, running off with a slimy little city boy called Duane and destroying my faith in everything which is good and pure.
Brian: So it didn't really work then.
Tim: No, it made me wanna drown things!"
It's got everything for me: the bit about borrowing one use items; Rembrandt being dead being a backfire; Brian's softness on the line "she's drowning"; a little Tim tirade and possibly my favourite line ever "No it made me wanna drown things!"
I use that in general conversation to express my distaste for something